Dr. Reeves, Pain Management Clinic: Real Hope with Dextrose and Platelet Prolotherapy
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​Knee Osteoarthritis 

RCT # 1:  Reeves KD, Hassanein K. Randomized prospective double-blind placebo-controlled study of dextrose prolotherapy for knee osteoarthritis with or without ACL laxity  Alt Ther Hlth Med 2000;6(2):68-80.
                                                                                             ABSTRACT   
CONTEXT: Use of prolotherapy (injection of growth factors or growth factor stimulators).
OBJECTIVE: Determine the effects of dextrose prolotherapy on knee osteoarthritis with or without anterior cruciate ligament (ACL) laxity.
DESIGN: Prospective randomized double-blind placebo-controlled trial.
SETTING: Outpatient physical medicine clinic.
PATIENTS OR OTHER PARTICIPANTS: Six months or more of pain along with either grade 2 or more joint narrowing or grade 2 or more osteophytic change in any knee compartment. A total of 38 knees were completely void of cartilage radiographically in at least 1 compartment.
INTERVENTION: Three bimonthly injections of 9 cc of either 10% dextrose and .075% lidocaine in bacteriostatic water (active solution) versus an identical control solution absent 10% dextrose. The dextrose-treated joints then received 3 further bimonthly injections of 10% dextrose in open-label fashion.
MAIN OUTCOME MEASURES: Visual analogue scale for pain and swelling, frequency of leg buckling, goniometrically measured flexion, radiographic measures of joint narrowing and osteophytosis, and KT1000-measured anterior displacement difference (ADD).
RESULTS: All knees: Hotelling multivariate analysis of paired observations between 0 and 6 months for pain, swelling, buckling episodes, and knee flexion range revealed significantly more benefit from the dextrose injection (P = .015). By 12 months (6 injections) the dextrose-treated knees improved in pain (44% decrease), swelling complaints (63% decrease), knee buckling frequency (85% decrease), and in flexion range (14 degree increase). Analysis of blinded radiographic readings of 0- and 12-month films revealed stability of all radiographic variables except for 2 variables which improved with statistical significance. (Lateral patellofemoral cartilage thickness [P = .019] and distal femur width in mm [P = .021]. Knees with ACL laxity: 6-month (3 injection) data revealed no significant improvement. However, Hotelling multivariate analysis of paired values at 0 and 12 months for pain, swelling, joint flexion, and joint laxity in the dextrose-treated knees, revealed a statistically significant improvement (P = .021). Individual paired t tests indicated that blinded measurement of goniometric kneeflexion range improved by 12.8 degrees (P = .005), and ADD improved by 57% (P = .025). Eight out of 13 dextrose-treated knees with ACLlaxity were no longer lax at the conclusion of 1 year.
CONCLUSION: Prolotherapy injection with 10% dextrose resulted in clinically and statistically significant improvements in knee osteoarthritis. Preliminary blinded radiographic readings (1-year films, with 3-year total follow-up period planned) demonstrated improvement in several measures of osteoarthritis severity. ACL laxity, when present in these osteoarthritic patients, improved.

RISK OF BIAS TABLE USING COCHRANE CRITERIA (Modified from Reeves KD, Sit RWS, Rabago D. Dextrose Prolotherapy: A narrative review of basic science and clinical research, and best treatment recommendations. Phys Med Rehabil Clin N Am; 2016; 27(4); 783-823;. DOI 10.1016/j.pmr.2016.06.001)
Sequence Generation
Allocation Concealment
Blinding of Participants & Researchers
Blinding of Outcome Assessment
Incomplete Outcome Data Addressed
Selective Data Reporting
Low​
Unclear
Low
Low
High
Unclear 
A random number table was utilized
Relevant information was not reported
Identical control solution was used
Assessor and database coordinator masked
Data loss (9/77 [11.7%]; >10%). 
No protocol provided 
                                                                     SUMMARY of Reeves et al Knee OA RCT
Reeves et al. compared DPT to blinded lidocaine injections in a 2 arm blinded trial using an intraarticular-only injection protocol (Figure 12, table 2) Participants with chronic knee pain and Kellgren-Lawrence (KL) stage II-IV radiographic knee OA received injections at 0, 2 and 4 months, with optional open label dextrose injection after 6 months. This study has a large percentage of stage IV osteoarthritic knee with 38 knees avoid of cartilage in at least one compartment.  Primary measures were 0-10 NRS for walking pain and goniometrically-measured knee range of motion.  Participants had statistically similar baseline characteristics. Range of motion gains favored the DPT group at 6-months (13.2± 2.1 degrees vs 7.7 ± 2.2 degrees; p=.015). The two groups did not have a statistical significant difference in walking pain. (Figure 13) However, the DPT group showed continuing improvement to 12-months, and the lidocaine group, after un-blinding, received DPT, and also showed continuing improvement to 12 months. (Figure 13).   

RCT # 2:  Dumais R, Benoit C, Dumais A, et al. Effect of regenerative injection therapy on function and pain in patients with knee osteoarthritis: a randomized crossover study. Pain Med. 2012;13(8):990-999.
                                                                                             ABSTRACT   
OBJECTIVE: We assessed the effectiveness of regenerative injection therapy (RIT) to relieve pain and restore function in patients with kneeosteoarthritis.
DESIGN: Crossover study where participants were randomly assigned to receive exercise therapy for 32 weeks in combination with RIT on weeks 0, 4, 8, and 12 or RIT on weeks 20, 24, 28, and 32.
PATIENTS:  Thirty-six patients with chronic knee osteoarthritis.
INTERVENTIONS: RIT, which is made up of injections of 1 cc of 15% dextrose 0.6% lidocaine in the collateral ligaments and a 5 cc injectionof 20% dextrose 0.5% lidocaine inside the knee joint.
OUTCOME MEASURES:  The primary outcome was the Western Ontario and McMaster Universities Osteoarthritis Index of severity of osteoarthrosis symptoms (WOMAC) score (range: 0-96).
RESULTS: Following 16 weeks of follow-up, the participants assigned to RIT presented a significant reduction of their osteoarthritis symptoms (mean ± standard deviation: -21.8 ± 12.5, P < 0.001). WOMAC scores in this group did not change further during the last 16 weeks of follow-up, when the participants received exercise therapy only (-1.2 ± 10.7, P = 0.65). WOMAC scores in the first 16 weeks did not change significantly among the participants receiving exercise therapy only during this period (-6.1±13.9, P=0.11). There was a significant decrease in this groups' WOMAC scores during the last 16 weeks when the participants received RIT (-9.3±11.4, P=0.006). After 36 weeks, WOMAC scores improved in both groups by 47.3% and 36.2%. The improvement attributable to RIT alone corresponds to a 11.9-point (or 29.5%) decrease in WOMAC scores.
CONCLUSIONS: The use of RIT is associated with a marked reduction in symptoms, which was sustained for over 24 weeks.

RISK OF BIAS TABLE USING COCHRANE CRITERIA (Modified from Reeves KD, Sit RWS, Rabago D. Dextrose Prolotherapy: A narrative review of basic science and clinical research, and best treatment recommendations. Phys Med Rehabil Clin N Am; 2016; 27(4); 783-823;. DOI 10.1016/j.pmr.2016.06.001)
Sequence Generation
Allocation Concealment
Blinding of Participants & Researchers
Blinding of Outcome Assessment
Incomplete Outcome Data Addressed
Selective Data Reporting
Unclear
Low
High
Low
High
Unclear 
Random sequencing method not described
Opaque sealed envelopes were used
Randomized open label  groups
Outcome assessors masked to group
>10% lost to follow-up from each group
No protocol provided 
                                                     Summary of Dumais et al  knee RCT
Dumais et al compared DPT plus a home-based physical therapy program to home-based physical therapy alone in a randomized crossover trial. (Figure 16, table 2) Participants with chronic knee pain and any KL grading received injections at 0, 4, 8, and 12 weeks of 20% dextrose intra-articularly and 15% dextrose in coronary and collateral ligaments versus therapy only. Assessments were performed at week 16. After that, the 2 arms crossed over with a second assessment at week 36.  Participants had statistically similar baseline characteristics, and 86% were Kelgren III or IV. Improvement in composite WOMAC score was significantly more in the group receiving DPT for period 1 (21.8±12.5 vs 6.1±13.9; p<.05) and period 2 (9.3±11.4 vs 1.2±10.7; p<.05) with an overall significance of p <.001 using a standard statistical method of cross-over design analysis.51 (Figure 17). 

RCT # 3:  Rabago D, Patterson JJ, Mundt M, et al. Dextrose prolotherapy for knee osteoarthritis: a randomized controlled trial. Annals of family medicine 2013;11:229-37.​
                                                                                             ABSTRACT

​
RISK OF BIAS TABLE USING COCHRANE CRITERIA 
(Modified from Reeves KD, Sit RWS, Rabago D. Dextrose Prolotherapy: A narrative review of basic science and clinical research, and best treatment recommendations. Phys Med Rehabil Clin N Am; 2016; 27(4); 783-823;. DOI 10.1016/j.pmr.2016.06.001)   

​
Sequence Generation
Allocation Concealment
Blinding of Participants & Researchers
Blinding of Outcome Assessment
Incomplete Outcome Data Addressed
Selective Data Reporting
Low
Low
Low
Low
Low
Unclear 
Random sequence generated by computer
Off-site assignment and opaque sealed envelopes
​(Both active and control solutions looked similar)
​Outcome assessor masked to group allocation
No participants were lost to follow-up 
No protocol provided 
                                                      Summary of Rabago et al  knee RCT
Rabago et al. conducted a 3-arm RCT comparing DPT to normal saline injection and a home-based exercise.52 (Figure 18, table 2) Participants with chronic knee pain and any radiological evidence of OA by KL grading were randomized to receive injection at 1, 5, and 9 weeks with optional treatments at 13 and 17 weeks consistent with a published protocol53. Effects were assessed using the WOMAC questionnaire at 0, 5, 9, 12, 26, and 52 weeks.
Participants had statistically similar baseline characteristics and 63% were rated Kelgren III-IV. By 9 weeks, participants receiving DPT reported substantial improvement in the WOMAC composite score (13.91 ± 3.2 points) compared with both control therapies. (Figure 19) Maximum benefits were recorded by 24 weeks and persisted through 52 weeks. At 52 weeks the DPT group improved more than either the saline injection or exercise groups in WOMAC composite score (15.3±3.3 vs 7.6±3.4 vs 8.2±3.3: p<.05). (Figure 19) 
​
RCT # 4:  Sit RWS, Wu RWK, Rabago D, Reeves KD, Chan DCC, Yip BHK, Chung VCH, Wong SYS. Efficacy of Intra-Articular Hypertonic Dextrose (Prolotherapy) for Knee Osteoarthritis: A Randomized Controlled Trial. Ann Fam Med. 2020 May;18(3):235-242.
Here is the link to the PDF  for the entire article from the the National Library of Medicine secure website
Link to Sit et al. RCT on KNEE OA treatment
And here is  a summary of the study and its findings
•Design:  Randomized, double-blind clinical trial comparing four monthly intraarticular injections into the suprapatellar pouch with ultrasound guidance of 5 ml of 25% dextrose in water versus 5 ml normal saline. 
•Candidates:  Knee pain ≥ three months, failure of 6 months of conservative care. (No severity restriction)
•Study size:  76 participants (38 in each group)
•Bias:  Off-site randomization using random allocation software. Sealed envelopes with gruop assignment were not  opened by the syringe preparer until after time 0 data was gathered, ensuring blind allocation as the syringe preparer has no interaction with study personnel. Blinding was maintained throughout the entire 12 months.  The syringes were wrapped to mask viscosity.  
•Measures:  Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at 1 year. 
•ITT versus Per Protocol:   This was by intention to treat equivalent as linear mixed model analysis takes lost data into account.  There were only 2 dropouts, both from NS group, who were lost to follow-up at one year.
•Other treatments:  Usual care was allowed in both groups. Other injection therapies were to be avoided. Other care was tracked for between-group differences with no difference indicated in amount of usual care. 
•Results:  The dextrose prolotherapy (DPT) group outperformed saline injection for improvements in WOMAC pain score (P =.022), function score (P=.014), and composite score (P = .020) , although satisfaction was high in both groups.  WOMAC score improvement exceeded the composite WOMAC MCID of 12 points.
•Limitations: Saline is not a placebo control.  Nevertheless, DPT outperformed a potentially active control
•Bottom Line 2020 Sit: 4 monthly IA DPT  injections  outerperformed 4 monthly saline injections @ 1 yr
​

RCT # 5:  Sert AT, Sen EI, Esmaeilzadeh S, Ozcan E. The Effects of Dextrose Prolotherapy in Symptomatic Knee Osteoarthritis: A Randomized Controlled Study. J Altern Complement Med. 2020 May;26(5):409-417.
Here is the link to the study abtract from a secure PubMed website 
Link to Sert el al. abstract
Here is a summary of the study design and findings
• Design:  Randomized single-blind (for injection groups) clinical trial.  3 injection sessions (0, 3, and 6 weeks) intraarticular into patellofemoral joint (5 ml 15% dextrose /.25% lidocaine) and extraarticular areas (10 ml, divided between collateral and coronary ligaments, superior patellar pole, patellar tendon tibial attachment and pes anserinus) versus .45%saline/.5% lidocaine  in same volume and distribution versus only home-based therapy. 
• Candidates:  Grade II or II KOA , symptomatic for > 3 months, failure of conservative treatment methods for an unspecified period. 
• Study size:  66 participants  (22 in each of 3 groups)  
• Bias:  Group assignments were made by independent blinded research using computer-generated random numbers.  The injector was not blinded but the rest of the team was.  Allocation was described, specificallly whether baseline data was gathered before or after the  group assignment was revealed to the injecting physician. 
• Measures:  Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Health-Related Quality of Life Scores (HRQoL) at  18 weeks.  
• ITT versus Per Protocol Analysis: Per protocol, but only one was lost from the DPT group for personal reasons and three from the exercise-only group. 
• Other treatments: All participants received home-based therapies with tracking phone calls for education and encouragement.   
• Results:  At 18 weeks the DPT group outperformed saline injection for improvements in WOMAC pain score (P =.002), function score (P<.001), and composite score (P = .002). Saline group outperformed exercise control in WOMAC function (P=.003) and composite score (P<.001). WOMAC  composite scores improved by 36, 22.5, and 9.5 for  DPT, Saline, and exercise groups.
• Limitations:  18-week follow-up is short. 
• Strengths: Had a non injection control as well, similar to Rabago et al 2013 and used an intraarticular + extraarticular injection as well. 
•Bottom Line 2020 Sert:  3 biweekly DPT injections both IA + EA > IA+EA NS > Exercise @ 18 weeks. 
RCT # 5:  Chowdhury ZR, Mohammed SA, Khasru MR, et al. Pain and functional outcome with single dose 25% dextrose intra-articular injection in patients with primary osteoarthritis of the knee. Journal of Dhaka Medical College 2021;29:138-44.
Here is a link to the entire article 
Link to journal site to get a full PDF
buHere is the abstact along with a  comment 
Introduction: Osteoarthritis (OA) is the most prevalent chronic joint disorder worldwide and is associated with significant pain and disability. The introduction of 25% Dextrose injection has been viewed as an advance in the management of OA knee.
Methods: A prospective, randomized clinical trial was conducted with 84 cases in the Physical Medicine and Rehabilitation (PMR) department of BSMMU. Group A, 42 patients received single dose 25% Dextrose injection intra articular 8ml, exercise and ADL; Group B, 42 patients received exercise and ADL. Outcomes were measured by OA specific translated and validated Bengali instrument- Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire and visual analogue scale (VAS 0-10). They were followed up for 6 months.
Result: At the initial stage and in week 4, there was no statistical difference between two groups regarding VAS score (as p value was >0.05). But in week 12 and 24, there was highly significant statistical difference regarding VAS score between two groups as the p value was <0.001. Again at the initial stage and week 4, there was no statistical difference between two groups regarding stiffness and physical function score. But in week 12 and 24, there was significant statistical difference regarding stiffness and physical function score between two groups as the p value was less than 0.05.
Conclusion: Intra-articular injection of 25% dextrose administered to patients with OA knee has significant effects in pain reduction and functional improvement
COMMENTS:  Not only is the treatment simple here (Inside the knee only), but it compares  a simple common knee exercise (active quadriceps  strengthening 10 repetitions twice daily) to the same exercise accompanied by just one injection of dextrose.  A look at the magnitude of outcomes showed a pain improvement of 6.74 to 4.33 on a 10 point scale which is clinically important.  (A 2.0 change on a 10 point scale is considered clinically important.)   Unfortunately a non-standard scoring was used for the WOMAC. Even more concerning is what appears to be somed  significant statistical limitations. For example the change score difference between groups is not consistent with the between groups differences mentioned in their output.  Nevertheless a total score difference of 31% in the dextrose group versus 16% in the exercise only group indicates a clinically important change in function.


"Real Hope for Chronic Pain"
We use dextrose and platelet prolotherapy to eliminate the causes of chronic pain.
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  • Dr. Reeves, Prolotherapy, Kansas City
    • Prolo/PIT: Brief Summary of Both
    • Comparing Prolotherapy and PIT
    • FAQ: About Prolotherapy
  • RESEARCH
    • Basic Science Dextrose >
      • Analgesia
      • Chondrogenesis
      • Tendon injection safe
      • Thickens lIgament
    • Dextrose RCTs >
      • Achilles Tendinopathy
      • Ankle Osteoarthritis
      • Chondromalacia patella
      • Fibromyalgia
      • Hand Osteoarthritis
      • Hip Osteoarthritis
      • Knee Osteoarthritis
      • Lateral Epicondylosis
      • Low Back/Sacroiliac Pain
      • Osgood-Schlatter Disease
      • Plantar Fasciosis
      • Rotator Cuff Tendinopathy
      • Temporomandibular Dysfunction
    • Dextrose Non RCTs >
      • ACL Laxity
      • Groin Pain
      • Patellar Tendinosis
      • Shin Splints
    • PIT Basic Science & Mechanism
    • PIT RCTS >
      • CARPAL TUNNEL SYNDROME
      • CUBITAL TUNNEL SYNDROME
    • FINDING RESEARCH
  • TRAINING IN PROLO/PIT
  • PATIENTS
    • PRP Use
    • Stem Cell Use
    • New Patient Intake Forms
    • What to expect in more detail
    • Directions to Office
    • Fiinding a Doctor
    • When Will I Feel Better With Prolotherapy?
  • HOPE